sciatic nerve transection;
bone marrow stromal cells;
cellular therapy;
regeneration;
D O I:
10.1179/016164104225013897
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Cell therapy using bone marrow stromal cells is a new promising therapy for regenerative medicine. Previous studies demonstrated that local bone marrow stromal cells implantation in the distal stump of transected sciatic nerve of rats promotes early functional recovery. The purpose of this study was to expand on the preliminary research by investigating the long-term efficacy of bone marrow stromal cells using the same experimental setting. Functional test and histological studies demonstrate that bone marrow stromal cell-treated rats exhibit significant improvement on a walking tract test at day 180 after surgery compared with control rats. Taken together, these data suggest that bone marrow stromal cell therapy is a safe and effective strategy for peripheral nerve injuries.
机构:
Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, SpainUniv Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Cuevas, P
;
Carceller, F
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Carceller, F
;
Dujovny, M
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Dujovny, M
;
Garcia-Gómez, I
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Garcia-Gómez, I
;
Cuevas, B
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Cuevas, B
;
González-Corrochano, R
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
González-Corrochano, R
;
Diaz-González, D
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Diaz-González, D
;
Reimers, D
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h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
机构:
Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, SpainUniv Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Cuevas, P
;
Carceller, F
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Carceller, F
;
Dujovny, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Dujovny, M
;
Garcia-Gómez, I
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Garcia-Gómez, I
;
Cuevas, B
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Cuevas, B
;
González-Corrochano, R
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
González-Corrochano, R
;
Diaz-González, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain
Diaz-González, D
;
Reimers, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Ramon y Cajal, E-28034 Madrid, Spain