Bone marrow stromal cell implantation for peripheral nerve repair

被引:108
作者
Cuevas, P [1 ]
Carceller, F
Garcia-Gómez, I
Yan, M
Dujovny, M
机构
[1] Univ Alcala de Henares, Serv Histol, Dept Invest, Hosp Univ Ramon & Cajal, E-28034 Madrid, Spain
[2] Wayne State Univ, Dept Neurosurg, Detroit, MI USA
[3] Hosp Jingxi, Beijing, Peoples R China
关键词
sciatic nerve transection; bone marrow stromal cells; cellular therapy; regeneration;
D O I
10.1179/016164104225013897
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cell therapy using bone marrow stromal cells is a new promising therapy for regenerative medicine. Previous studies demonstrated that local bone marrow stromal cells implantation in the distal stump of transected sciatic nerve of rats promotes early functional recovery. The purpose of this study was to expand on the preliminary research by investigating the long-term efficacy of bone marrow stromal cells using the same experimental setting. Functional test and histological studies demonstrate that bone marrow stromal cell-treated rats exhibit significant improvement on a walking tract test at day 180 after surgery compared with control rats. Taken together, these data suggest that bone marrow stromal cell therapy is a safe and effective strategy for peripheral nerve injuries.
引用
收藏
页码:230 / 232
页数:3
相关论文
共 18 条
[1]   Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].
Azizi, SA ;
Stokes, D ;
Augelli, BJ ;
DiGirolamo, C ;
Prockop, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3908-3913
[2]   Cell replacement therapies for central nervous system disorders [J].
Björklund, A ;
Lindvall, O .
NATURE NEUROSCIENCE, 2000, 3 (06) :537-544
[3]   Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation [J].
Chopp, M ;
Zhang, XH ;
Li, Y ;
Wang, L ;
Chen, JL ;
Lu, DY ;
Lu, M ;
Rosenblum, M .
NEUROREPORT, 2000, 11 (13) :3001-3005
[4]   Peripheral nerve regeneration by bone marrow stromal cells [J].
Cuevas, P ;
Carceller, F ;
Dujovny, M ;
Garcia-Gómez, I ;
Cuevas, B ;
González-Corrochano, R ;
Diaz-González, D ;
Reimers, D .
NEUROLOGICAL RESEARCH, 2002, 24 (07) :634-638
[5]  
CUEVAS P, 2003, CELULAS TRONCALES HU, P63
[6]   Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells [J].
Dezawa, M ;
Takahashi, I ;
Esaki, M ;
Takano, M ;
Sawada, H .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (11) :1771-1776
[7]   Methods to evaluate functional nerve recovery in adult rats: walking track analysis, video analysis and the withdrawal reflex [J].
Dijkstra, JR ;
Meek, MF ;
Robinson, PH ;
Gramsbergen, A .
JOURNAL OF NEUROSCIENCE METHODS, 2000, 96 (02) :89-96
[8]   Adult stem cells and tissue repair [J].
Körbling, M ;
Estrov, Z ;
Champlin, R .
BONE MARROW TRANSPLANTATION, 2003, 32 :S23-S24
[9]   Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease [J].
Li, Y ;
Chen, JL ;
Wang, L ;
Zhang, L ;
Lu, M ;
Chopp, M .
NEUROSCIENCE LETTERS, 2001, 316 (02) :67-70
[10]   Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice [J].
Li, Y ;
Chopp, M ;
Chen, JL ;
Wang, L ;
Gautam, SC ;
Xu, SX ;
Zhang, ZG .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (09) :1311-1319