Genetic Basis of Alopecia Areata A Roadmap for Translational Research

被引:43
作者
Jabbari, Ali [1 ]
Petukhova, Lynn [1 ,2 ]
Cabral, Rita M. [1 ]
Clynes, Raphael [1 ,3 ,4 ]
Christiano, Angela M. [1 ,5 ]
机构
[1] Columbia Univ, Dept Dermatol, New York, NY 10032 USA
[2] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA
[3] Columbia Univ, Dept Med, New York, NY 10032 USA
[4] Columbia Univ, Dept Pathol, New York, NY 10032 USA
[5] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA
关键词
Alopecia areata; Autoimmune disease; Genetic; Translational research; GENOME-WIDE ASSOCIATION; MULTIPLE-SCLEROSIS; RHEUMATOID-ARTHRITIS; SUSCEPTIBILITY LOCI; CELIAC-DISEASE; IMMUNE-RESPONSES; THYROID DISEASE; RISK ALLELES; MOUSE MODEL; T-CELLS;
D O I
10.1016/j.det.2012.08.014
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Alopecia areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, the molecular and cellular mechanisms underlying this complex disease are still poorly understood, and rational treatments are lacking. Further efforts are necessary to clearly pinpoint the causes and molecular pathways leading to this disease and to find evidence-based treatments for AA. The authors focus on the central role of genetics for gaining insight into disease pathogenesis and setting the stage for the rational development of novel effective therapeutic approaches.
引用
收藏
页码:109 / +
页数:11
相关论文
共 91 条
[1]   CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris [J].
Abrams, JR ;
Lebwohl, MG ;
Guzzo, CA ;
Jegasothy, BV ;
Goldfarb, MT ;
Goffe, BS ;
Menter, A ;
Lowe, NJ ;
Krueger, G ;
Brown, MJ ;
Weiner, RS ;
Birkhofer, MJ ;
Warner, GL ;
Berry, KK ;
Linsley, PS ;
Krueger, JG ;
Ochs, HD ;
Kelley, SL ;
Kang, SW .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (09) :1243-1252
[2]   IL2RA/CD25 Gene Polymorphisms: Uneven Association with Multiple Sclerosis (MS) and Type 1 Diabetes (T1D) [J].
Alcina, Antonio ;
Fedetz, Maria ;
Ndagire, Dorothy ;
Fernandez, Oscar ;
Leyva, Laura ;
Guerrero, Miguel ;
Abad-Grau, Maria M. ;
Arnal, Carmen ;
Delgado, Concepcion ;
Lucas, Miguel ;
Izquierdo, Guillermo ;
Matesanz, Fuencisla .
PLOS ONE, 2009, 4 (01)
[3]   Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy [J].
Barahmani, N. ;
Lopez, A. ;
Babu, D. ;
Hernandez, M. ;
Donley, S. E. ;
Duvic, M. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2010, 35 (04) :409-416
[4]   History of atopy or autoimmunity increases risk of alopecia areata [J].
Barahmani, Nazila ;
Schabath, Matthew B. ;
Duvic, Madeleine .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 61 (04) :581-591
[5]   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].
Barrett, Jeffrey C. ;
Clayton, David G. ;
Concannon, Patrick ;
Akolkar, Beena ;
Cooper, Jason D. ;
Erlich, Henry A. ;
Julier, Cecile ;
Morahan, Grant ;
Nerup, Jorn ;
Nierras, Concepcion ;
Plagnol, Vincent ;
Pociot, Flemming ;
Schuilenburg, Helen ;
Smyth, Deborah J. ;
Stevens, Helen ;
Todd, John A. ;
Walker, Neil M. ;
Rich, Stephen S. .
NATURE GENETICS, 2009, 41 (06) :703-707
[6]   Familial aggregation of alopecia areata [J].
Blaumeiser, B ;
van der Groot, I ;
Fimmers, R ;
Hanneken, S ;
Ritzmann, S ;
Seymons, K ;
Betz, RC ;
Ruzicka, T ;
Wienker, TF ;
De Weert, J ;
Lambert, J ;
Kruse, R ;
Nöthen, MM .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 54 (04) :627-632
[7]  
Brajac Ines, 2010, Lijec Vjesn, V132, P365
[8]   Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].
Burton, Paul R. ;
Clayton, David G. ;
Cardon, Lon R. ;
Craddock, Nick ;
Deloukas, Panos ;
Duncanson, Audrey ;
Kwiatkowski, Dominic P. ;
McCarthy, Mark I. ;
Ouwehand, Willem H. ;
Samani, Nilesh J. ;
Todd, John A. ;
Donnelly, Peter ;
Barrett, Jeffrey C. ;
Davison, Dan ;
Easton, Doug ;
Evans, David ;
Leung, Hin-Tak ;
Marchini, Jonathan L. ;
Morris, Andrew P. ;
Spencer, Chris C. A. ;
Tobin, Martin D. ;
Attwood, Antony P. ;
Boorman, James P. ;
Cant, Barbara ;
Everson, Ursula ;
Hussey, Judith M. ;
Jolley, Jennifer D. ;
Knight, Alexandra S. ;
Koch, Kerstin ;
Meech, Elizabeth ;
Nutland, Sarah ;
Prowse, Christopher V. ;
Stevens, Helen E. ;
Taylor, Niall C. ;
Walters, Graham R. ;
Walker, Neil M. ;
Watkins, Nicholas A. ;
Winzer, Thilo ;
Jones, Richard W. ;
McArdle, Wendy L. ;
Ring, Susan M. ;
Strachan, David P. ;
Pembrey, Marcus ;
Breen, Gerome ;
St Clair, David ;
Caesar, Sian ;
Gordon-Smith, Katherine ;
Jones, Lisa ;
Fraser, Christine ;
Green, Elain K. .
NATURE, 2007, 447 (7145) :661-678
[9]   Contrasting genetic association of IL2RA with SLE and ANCA - associated vasculitis [J].
Carr, Edward J. ;
Clatworthy, Menna R. ;
Lowe, Christopher E. ;
Todd, John A. ;
Wong, Andrew ;
Vyse, Timothy J. ;
Kamesh, Lavanya ;
Watts, Richard A. ;
Lyons, Paul A. ;
Smith, Kenneth G. C. .
BMC MEDICAL GENETICS, 2009, 10
[10]   Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans [J].
Carroll, JM ;
McElwee, KJ ;
King, LE ;
Byrne, MC ;
Sundberg, JP .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (02) :392-402