Genetic Basis of Alopecia Areata A Roadmap for Translational Research

被引：43

作者：

Jabbari, Ali ^{[1
]}

Petukhova, Lynn ^{[1
,2
]}

Cabral, Rita M. ^{[1
]}

Clynes, Raphael ^{[1
,3
,4
]}

Christiano, Angela M. ^{[1
,5
]}

机构：

[1] Columbia Univ, Dept Dermatol, New York, NY 10032 USA

[2] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA

[3] Columbia Univ, Dept Med, New York, NY 10032 USA

[4] Columbia Univ, Dept Pathol, New York, NY 10032 USA

[5] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

来源：

DERMATOLOGIC CLINICS | 2013年 / 31卷 / 01期

关键词：

Alopecia areata; Autoimmune disease; Genetic; Translational research; GENOME-WIDE ASSOCIATION; MULTIPLE-SCLEROSIS; RHEUMATOID-ARTHRITIS; SUSCEPTIBILITY LOCI; CELIAC-DISEASE; IMMUNE-RESPONSES; THYROID DISEASE; RISK ALLELES; MOUSE MODEL; T-CELLS;

D O I：

10.1016/j.det.2012.08.014

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Alopecia areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, the molecular and cellular mechanisms underlying this complex disease are still poorly understood, and rational treatments are lacking. Further efforts are necessary to clearly pinpoint the causes and molecular pathways leading to this disease and to find evidence-based treatments for AA. The authors focus on the central role of genetics for gaining insight into disease pathogenesis and setting the stage for the rational development of novel effective therapeutic approaches.

引用

页码：109 / +

页数：11

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