The target of acute stroke therapy and neuroprotective therapeutic approaches

被引：7

作者：

Fisher, M ^{[1
]}

机构：

[1] Univ Massachusetts, Med Ctr, Worcester, MA 01605 USA

来源：

REVISTA DE NEUROLOGIA | 1999年 / 29卷 / 06期

关键词：

cerebral ischemia; ischemic penumbra; neuroprotection; stroke; therapeutic window;

D O I：

10.33588/rn.2906.99174

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this article we review the concept of ischemic penumbra and emphasize the potentially reversible aspect as a function of time, which is the basis of the concept of a therapeutic window. Also, we briefly consider the physiopathology of the ischemic cascade emphasizing the levels at which the different neuroprotector drugs under investigation have their effect.

引用

收藏

页码：536 / 544

页数：9

相关论文

共 80 条

[61] INTERCONVERSION OF STROKE SCALES - IMPLICATIONS FOR THERAPEUTIC TRIALS [J].

MUIR, KW ;

GROSSET, DG ;

LEES, KR .

STROKE, 1994, 25 (07) :1366-1370

[62] Dose optimization of intravenous magnesium sulfate after acute stroke [J].

Muir, KW ;

Lees, KR .

STROKE, 1998, 29 (05) :918-923

[63] COMBINED PERFUSION AND DIFFUSION-WEIGHTED MAGNETIC-RESONANCE-IMAGING IN A RAT MODEL OF REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION [J].

MULLER, TB ;

HARALDSETH, O ;

JONES, RA ;

SEBASTIANI, G ;

GODTLIEBSEN, F ;

LINDBOE, CF ;

UNSGARD, G .

STROKE, 1995, 26 (03) :451-457

[64] Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats [J].

Onal, MZ ;

Li, FH ;

Tatlisumak, T ;

Locke, KW ;

Sandage, BW ;

Fisher, M .

STROKE, 1997, 28 (05) :1060-1065

[65]

Onal MZ, 1997, EUR NEUROL, V38, P141

[66] Cytokines and cell adhesion molecules in cerebral ischemia - Experimental bases and therapeutic perspectives [J].

Pantoni, L ;

Sarti, C ;

Inzitari, D .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (04) :503-513

[67] Nitric oxide synthase in models of focal ischemia [J].

Samdani, AF ;

Dawson, TM ;

Dawson, VL .

STROKE, 1997, 28 (06) :1283-1288

[68] The effects of prolonged treatment with citicoline in temporary experimental focal ischemia [J].

Schabitz, WR ;

Weber, J ;

Takano, K ;

Sandage, BW ;

Locke, KW ;

Fisher, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1996, 138 (1-2) :21-25

[69] Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats [J].

Schabitz, WR ;

Schwab, S ;

Spranger, M ;

Hacke, W .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (05) :500-506

[70]

Scott P, 1996, STROKE, V27, P1453

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