Alterations of white matter connectivity in first episode schizophrenia

被引：98

作者：

Federspiel, Andrea

Begre, Stefan ^{[1
]}

Kiefer, Claus

Schroth, Gerhard

Strik, Werner K.

Dierks, Thomas

机构：

[1] Univ Bern, Inselspital, Div Psychosomat Med, Dept Gen Internal Med, CH-3010 Bern, Switzerland

[2] Univ Hosp Clin Psychiat, Dept Psychiat Neurophysiol, Bern, Switzerland

[3] Univ Bern, Inselspital, Dept Neuroradiol, Bern, Switzerland

来源：

NEUROBIOLOGY OF DISEASE | 2006年 / 22卷 / 03期

关键词：

intervoxel coherence; fractional anisotropy; diffusion tensor imaging; gray matter; white matter; first episode schizophrenia;

D O I：

10.1016/j.nbd.2006.01.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebral disconnectivity due to white matter alterations in patients with chronic schizophrenia assessed by diffusion tensor imaging has been reported previously. The aim of this preliminary study is to investigate whether cerebral disconnectivity can be detected as early as the first episode of schizophrenia. Intervoxel coherence values were compared by voxel-based t test in 12 patients with first episode schizophrenia and 12 age- and gender-matched control groups. We detected 14 circumscribed significant clusters (P < 0.02), 3 of them with higher, and 11 of them with lower IC values for patients with schizophrenia than for healthy control groups. We interpret these white matter alterations in different regions to be disconnected fiber tracts already present early in schizophrenic disease progression. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：702 / 709

页数：8

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