Anti-quorum sensing activity of essential oils from Colombian plants

被引：44

作者：

Jaramillo-Colorado, Beatriz ^{[1
,2
]}

Olivero-Verbel, Jesus ^{[1
]}

Stashenko, Elena E. ^{[3
]}

Wagner-Doebler, Irene ^{[4
]}

Kunze, Brigitte ^{[4
]}

机构：

[1] Univ Cartagena, Fac Pharmaceut Sci, Environm & Computat Chem Grp, Cartagena, Colombia

[2] Univ Cartagena, Fac Exact & Nat Sci, Agrochem Res Grp, Chem Program, Cartagena, Colombia

[3] Ind Univ Santander, CENIVAM, CIBIMOL, Chromatog Lab,Res Ctr Biomolecules, Bucaramanga, Colombia

[4] Helmholtz Ctr Infect Res, Grp Microbial Commun, Braunschweig, Germany

来源：

NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 12期

关键词：

essential oil; Colombian plants; quorum sensing; VOLATILE SECONDARY METABOLITES; CHEMICAL-COMPOSITION; ANTICONVULSANT ACTIVITY; ANTIMICROBIAL ACTIVITY; DIFFERENT EXTRACTION; MEDICINAL-PLANTS; ANTIOXIDANT; ANTIBACTERIAL; SIGNALS; L;

D O I：

10.1080/14786419.2011.557376

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Essential oils from Colombian plants were characterised by GC-MS, and assayed for anti-quorum sensing activity in bacteria sensor strains. Two major chemotypes were found for Lippia alba, the limonene-carvone and the citral (geranial-neral). For other species, the main components included alpha-pinene (Ocotea sp.), beta-pinene (Swinglea glutinosa), cineol (Elettaria cardamomun), alpha-zingiberene (Zingiber officinale) and pulegone (Minthostachys mollis). Several essential oils presented promising inhibitory properties for the short chain AHL quorum sensing (QS) system, in Escherichia coli containing the biosensor plasmid pJBA132, in particular Lippia alba. Moderate activity as anti-QS using the same plasmid, were also found for selected constituents of essential oils studied here, such as citral, carvone and alpha-pinene, although solely at the highest tested concentration (250 mu g mL(-1)). Only citral presented some activity for the long chain AHL QS system, in Pseudomonas putida containing the plasmid pRK-C12. In short, essential oils from Colombian flora have promising properties as QS modulators.

引用

页码：1075 / 1086

页数：12

共 51 条

[21] Chemical analysis, antioxidant, anti inflammatory and anticholinesterase activities of Origanum ehrenbergii Boiss and Origanum syriacum L. essential oils [J].