The evolution and functional diversification of animal microRNA genes

被引：110

作者：

Liu, Na ^{[1
]}

Okamura, Katsutomo ^{[1
]}

Tyler, David M. ^{[1
]}

Phillips, Michael D. ^{[1
]}

Chung, Wei-Jen ^{[1
]}

Lai, Eric C. ^{[1
]}

机构：

[1] Sloan Kettering Inst, Dept Dev Biol, Rockefeller Res Labs 521, New York, NY 10065 USA

来源：

CELL RESEARCH | 2008年 / 18卷 / 10期

关键词：

microRNA; evolution; subfunctionalization; neofunctionalization;

D O I：

10.1038/cr.2008.278

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNAs (miRNAs) are an abundant class of similar to 22 nucleotide (nt) regulatory RNAs that are pervasive in higher eukaryotic genomes. In order to fully understand their prominence in genomes, it is necessary to elucidate the molecular mechanisms that can diversify miRNA activities. In this review, we describe some of the many strategies that allow novel miRNA functions to emerge, with particular emphasis on how miRNA genes evolve in animals. These mechanisms include changes in their sequence, processing, or expression pattern; acquisition of miRNA* functionality or antisense processing; and de novo gene birth. The facility and versatility of miRNAs to evolve and change likely underlies how they have become dominant constituents of higher genomes.

引用

页码：985 / 996

页数：12

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