User-friendly methylation of aryl and vinyl halides and pseudohalides with DABAL-Me3

被引：64

作者：

Cooper, T

Novak, A

Humphreys, LD

Walker, MD

Woodward, S

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 06期

关键词：

alkylation; aluminium; aryl halides; cross-coupling; palladium; vinyl halides;

D O I：

10.1002/adsc.200505405

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An extremely technically simple cross-methylation of aryl and vinyl halides and pseudohalides using an air-stable adduct of trimethylaluminium with a Pd(0) catalyst supported by commercially available biarylphosphines gives excellent yields of methylated products (mainly > 95%). Reactions can be run with either 0.5 mol % catalyst or without requiring the exclusion of atmospheric oxygen or the drying of solvents in some cases. A wide variety of functional groups is tolerated including CN, OH, CO2R, CHO and NO2.

引用

收藏

页码：686 / 690

页数：5

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