Rho GTPase signalling pathways in the morphological changes associated with apoptosis

被引：199

作者：

Coleman, ML ^{[1
]}

Olson, MF ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res Campaign, Ctr Cell & Mol Biol, London SW3 6JB, England

来源：

CELL DEATH AND DIFFERENTIATION | 2002年 / 9卷 / 05期

关键词：

Rho; Rac; ROCK; actin cytoskeleton; myosin light chain; phagocytosis; blebbing;

D O I：

10.1038/sj.cdd.4400987

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture, In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.

引用

页码：493 / 504

页数：12

共 168 条

[1] IDENTIFICATION OF A NOVEL PROTEIN WITH GDP DISSOCIATION INHIBITOR ACTIVITY FOR THE RAS-LIKE PROTEINS CDC42HS AND RAC-I [J].

ADRA, CN ;

KO, J ;

LEONARD, D ;

WIRTH, LJ ;

CERIONE, RA ;

LIM, B .

GENES CHROMOSOMES & CANCER, 1993, 8 (04) :253-261

[2] αvβ5 integrin recruits the Crkll-Dock180-Rac1 complex for phagocytosis of apoptotic cells [J].

Albert, ML ;

Kim, JI ;

Birge, RB .

NATURE CELL BIOLOGY, 2000, 2 (12) :899-905

[3] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].

Albert, ML ;

Sauter, B ;

Bhardwaj, N .

NATURE, 1998, 392 (6671) :86-89

[4] Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages [J].

Allen, LAH ;

Aderem, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :627-637

[5] Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase [J].

Amano, M ;

Chihara, K ;

Kimura, K ;

Fukata, Y ;

Nakamura, N ;

Matsuura, Y ;

Kaibuchi, K .

SCIENCE, 1997, 275 (5304) :1308-1311

[6] The COOH terminus of Rho-kinase negatively regulates Rho-kinase activity [J].

Amano, M ;

Chihara, K ;

Nakamura, N ;

Kaneko, T ;

Matsuura, Y ;

Kaibuchi, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) :32418-32424

[7] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) [J].

Amano, M ;

Ito, M ;

Kimura, K ;

Fukata, Y ;

Chihara, K ;

Nakano, T ;

Matsuura, Y ;

Kaibuchi, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) :20246-20249

[8] LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505 [J].

Amano, T ;

Tanabe, K ;

Eto, T ;

Narumiya, S ;

Mizuno, K .

BIOCHEMICAL JOURNAL, 2001, 354 :149-159

[9] Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line [J].

Badock, V ;

Steinhusen, U ;

Bommert, K ;

Wittmann-Liebold, B ;

Otto, A .

CELL DEATH AND DIFFERENTIATION, 2001, 8 (03) :308-315

[10] Immune clearance of phosphatidylserine-expressing cells by phagocytes -: The role of β2-glycoprotein I in macrophage recognition [J].

Balasubramanian, K ;

Chandra, J ;

Schroit, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :31113-31117

← 1 2 3 4 5 6 7 8 9 10 →