Remote Optical Switch for Localized and Selective Control of Gene Interference

被引：170

作者：

Lee, Somin Eunice ^{[1
]}

Liu, Gang Logan ^{[2
]}

Kim, Franklin ^{[1
]}

Lee, Luke P. ^{[1
]}

机构：

[1] Univ Calif Berkeley, UCSF UCB Joint Grad Grp Bioengn, Dept Bioengn,Biomol Nanotechnol Ctr, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA

[2] Univ Illinois, Micro & Nanotechnol Lab 3104, Dept Elect & Comp Engn, Urbana, IL 61801 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GOLD NANORODS; ENCAPSULATED MATERIALS; PHOTOTHERMAL THERAPY; LIVING CELLS; DNA; NANOPARTICLES; EXPRESSION; HYBRIDIZATION; ACTIVATION; AZOBENZENE;

D O I：

10.1021/nl802689k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.

引用

页码：562 / 570

页数：9

共 43 条

[11] Fine-tuning the shape of gold nanorods [J].

Gou, LF ;

Murphy, CJ .

CHEMISTRY OF MATERIALS, 2005, 17 (14) :3668-3672

[12] HER2 overexpression as a prognostic factor in metastatic breast cancer patients treated with high-dose chemotherapy and autologous stem cell support [J].

Guarneri, V ;

Bengala, C ;

Orlandini, C ;

Gennari, A ;

Donati, S ;

Campani, D ;

Collecchi, P ;

Maur, M ;

Conte, PF .

BONE MARROW TRANSPLANTATION, 2004, 34 (05) :413-417

[13] Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna [J].

Hamad-Schifferli, K ;

Schwartz, JJ ;

Santos, AT ;

Zhang, SG ;

Jacobson, JM .

NATURE, 2002, 415 (6868) :152-155

[14]

HIRSCH LR, 2002, P 2 JOINT ENG MED BI, V1, P530

[15] Expression of plasmid DNA released from DNA conjugates of gold nanorods [J].

Horiguchi, Yukichi ;

Niidome, Takuro ;

Yamada, Sunao ;

Nakashima, Naotoshi ;

Niidome, Yasuro .

CHEMISTRY LETTERS, 2007, 36 (07) :952-953

[16]

Howard KA, 2007, SMALL, V3, P54, DOI 10.1002/small.200600328

[17] Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods [J].

Huang, XH ;

El-Sayed, IH ;

Qian, W ;

El-Sayed, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) :2115-2120

[18] Metafectene is superior to lipofectamine in the transfection of Gsα prostate cancer cells [J].

Iczhowski, KA ;

Omara-Opyene, AL ;

Klösel, R .

MOLECULAR BIOTECHNOLOGY, 2004, 28 (02) :97-103

[19] Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters [J].

Khlebtsov, Boris ;

Zharov, Vladimir ;

Melnikov, Andrei ;

Tuchin, Valery ;

Khlebtsov, Nikolai .

NANOTECHNOLOGY, 2006, 17 (20) :5167-5179

[20]

LEE E, 2006, 2006 MICRO TOTAL ANA

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