Remote Optical Switch for Localized and Selective Control of Gene Interference

被引：170

作者：

Lee, Somin Eunice ^{[1
]}

Liu, Gang Logan ^{[2
]}

Kim, Franklin ^{[1
]}

Lee, Luke P. ^{[1
]}

机构：

[1] Univ Calif Berkeley, UCSF UCB Joint Grad Grp Bioengn, Dept Bioengn,Biomol Nanotechnol Ctr, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA

[2] Univ Illinois, Micro & Nanotechnol Lab 3104, Dept Elect & Comp Engn, Urbana, IL 61801 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GOLD NANORODS; ENCAPSULATED MATERIALS; PHOTOTHERMAL THERAPY; LIVING CELLS; DNA; NANOPARTICLES; EXPRESSION; HYBRIDIZATION; ACTIVATION; AZOBENZENE;

D O I：

10.1021/nl802689k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.

引用

页码：562 / 570

页数：9

共 43 条

[21] Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals [J].

Link, S ;

El-Sayed, MA .

INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY, 2000, 19 (03) :409-453

[22] Site-specific incorporation of photoisomerizable azobenzene groups into ribonuclease S [J].

Liu, D ;

Karanicolas, J ;

Yu, C ;

Zhang, ZH ;

Woolley, GA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (20) :2677-2680

[23] Optofluidic control using photothermal nanoparticles [J].

Liu, GL ;

Kim, J ;

Lu, Y ;

Lee, LP .

NATURE MATERIALS, 2006, 5 (01) :27-32

[24] Gold nanoshell bioconjugates for molecular imaging in living cells [J].

Loo, C ;

Hirsch, L ;

Lee, MH ;

Chang, E ;

West, J ;

Halas, NJ ;

Drezek, R .

OPTICS LETTERS, 2005, 30 (09) :1012-1014

[25] Nanophotonic crescent moon structures with sharp edge for ultrasensitive biomolecular detection by local electromagnetic field enhancement effect [J].

Lu, Y ;

Liu, GL ;

Kim, J ;

Mejia, YX ;

Lee, LP .

NANO LETTERS, 2005, 5 (01) :119-124

[26] Size-dependent DNA mobility in cytoplasm and nucleus [J].

Lukacs, GL ;

Haggie, P ;

Seksek, O ;

Lechardeur, D ;

Freedman, N ;

Verkman, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (03) :1625-1629

[27] Targeting expression with light using caged DNA [J].

Monroe, WT ;

McQuain, MM ;

Chang, MS ;

Alexander, JS ;

Haselton, FR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :20895-20900

[28]

NIE S, 2007, ANU REV BIOMED ENG, V9

[29]

Nikoobakht B, 2003, CHEM MATER, V15, P1957, DOI 10.1021/cm0207321

[30] Targeted photothermal lysis of the pathogenic bacteria, Pseudomonas aeruginosa, with gold nanorods [J].

Norman, R. Sean ;

Stone, John W. ;

Gole, Arland ;

Murphy, Catherine J. ;

Sabo-Attwood, Tara L. .

NANO LETTERS, 2008, 8 (01) :302-306

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