Conformational studies of oligosaccharides and glycopeptides: Complementarity of NMR, X-ray crystallography, and molecular modelling

被引：350

作者：

Wormald, MR

Petrescu, AJ

Pao, YL

Glithero, A

Elliott, T

Dwek, RA

机构：

[1] Univ Oxford, Oxford Glycobiol Inst, Dept Biochem, Oxford OX1 3QU, England

[2] Romanian Acad, Inst Biochem, Bucharest 77700 17, Romania

[3] John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 02期

关键词：

D O I：

10.1021/cr990368i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of experimental and theoretical techniques gives considerable insight into oligosaccharide conformation. Through this, it became relatively straightforward to characterize the conformational properties of individual glycosidic linkages. Different types of linkages show different types of conformational behavior, one or more conformers, and different degrees of flexibility. A single type of linkage can show different behavior in different environments, the conformational freedom being further reduced by the surrounding residues.

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页码：371 / 386

页数：16

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