Molecular mechanisms of olfactory processing in the mammalian olfactory epithelium

被引:8
作者
Hatt, H
机构
[1] Department of Cell Physiology, Ruhr University, Bochum
来源
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1996年 / 58卷 / 04期
关键词
olfaction; transduction; cAMP-activated channels;
D O I
10.1159/000276834
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
In humans the sense of smell plays an important role in protecting the organism from external hazards like fire, gas or spoiled food, in the consumption of food and in chemical communication with one another. Increasingly, the study of human olfaction is relevant to a number of medical problems connected with olfactory dysfunction, i.e. neurodegenerative diseases which are also manifested in the olfactory epithelium. Although much is known about behavioral aspects and neuronal activities elicited by odorants, we still cannot clearly describe the molecular mechanisms by which odor stimuli are transformed into an electrical cell signal. Here recent progress in our knowledge about the molecular elements of the: transduction machinery are reviewed. It can help to understand the general principles underlying our sense of smell.
引用
收藏
页码:183 / 194
页数:12
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