Melatonin utility in neonates and children

被引：58

作者：

Chen, Yu-Chieh ^{[1
,2
]}

Tain, You-Lin ^{[1
,2
]}

Sheen, Jiunn-Ming ^{[1
,2
]}

Huang, Li-Tung ^{[1
,2
,3
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung, Taiwan

[2] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan

[3] Chang Gung Univ, Tao Yuan, Taiwan

来源：

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 2012年 / 111卷 / 02期

关键词：

antioxidant; children; melatonin; neonates; sleep disorders; RESPIRATORY-DISTRESS-SYNDROME; PERIVENTRICULAR WHITE-MATTER; CONTROLLED-RELEASE MELATONIN; PLACEBO-CONTROLLED TRIAL; OXIDATIVE STRESS; SLEEP DISORDERS; ANTIOXIDANT ENZYMES; SPECTRUM DISORDERS; LIPID-PEROXIDATION; PRETERM NEWBORNS;

D O I：

10.1016/j.jfma.2011.11.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melatonin (N-acetyl-5-methoxytryptamine) is an endogenously produced indoleamine secreted by the pineal gland and the secretion is suppressed by light. Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect. Plenty of evidence supports the utility of melatonin in adults for cancer, neurodegenerative disorders, and aging. In children and neonates, melatonin has been used widely, including for respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia (PVL), hypoxia ischemia encephalopathy and sepsis. In addition, melatonin can be used in childhood sleep and seizure disorders, and in neonates and children receiving surgery. This review article discusses the utility of melatonin in neonates and children. Copyright (C) 2012, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.

引用

页码：57 / 66

页数：10

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