Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry

被引：51

作者：

Castellari, M. ^{[1
]}

Gratacos-Cubarsi, M. ^{[1
]}

Garcia-Regueiro, J. A. ^{[1
]}

机构：

[1] IRTA Monells, Monells Girona 17121, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2009年 / 1216卷 / 46期

关键词：

Tandem mass spectrometry; Tetracycline; Oxytetracycline; Hair; FOOD-PRODUCING ANIMALS; ANALYTICAL STRATEGIES; VETERINARY DRUGS; ANTIBIOTICS; TISSUES; MISUSE;

D O I：

10.1016/j.chroma.2009.03.059

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An ultra-high-performance liquid chromatography tandem mass spectrometry method to detect residues of tetracycline (TC), epi-tetracycline (eTC) and oxytetracycline (OTC) in animal hair was developed. Hair samples were washed with water, extracted with NH(4)OH 0.1 M, purified by SPE-C(18) cartridge and analyzed by tandem mass spectrometry (ESI(+), MRM mode) with satisfactory results. For the first time, accumulation of TC, eTC and OTC was confirmed in livestock hairs after a therapeutic treatment with TC and OTC, respectively. Administered drug residues were detectable in hair samples up to 2 months after the last treatment, providing a retrospective evidence of TC and OTC administration. Hair analysis seems to offer a wider window of detection than edible tissues. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：8096 / 8100

页数：5

共 21 条

[1] ANALYTICAL STRATEGIES FOR THE SCREENING OF VETERINARY DRUGS AND THEIR RESIDUES IN EDIBLE PRODUCTS [J].