Composite nanocapsules: Lipid vesicles covered with several layers of crosslinked polyelectrolytes

被引：35

作者：

Germain, Matthieu

Grube, Stephan

Carriere, Virginie

Richard-Foy, Helene

Winterhalter, Mathias

Fournier, Didier

机构：

[1] CNRS, IPBS, UMR 5089, F-31077 Toulouse, France

[2] Prologue Biotech, Nanobiotix, F-31319 Labege, France

[3] UPS, CNRS, IEFG,UMR 5099, IFR 109,LBME, F-31062 Toulouse, France

[4] Int Univ Bremen, D-28726 Bremen, Germany

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 21期

关键词：

D O I：

10.1002/adma.200600860

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biologically active proteins are loaded into liposomes, which are then used as templates for the layer-by-layer deposition of polyelectrolytes. The multilayer polyelectrolyte layers are then crosslinked to form a robust protective barrier (see figure). Enzymes encapsulated within composite nanocapsules generated by this procedure are able to retain their substrate selectivity and activity even in the presence of detergent, suggesting the potential use of these structures as nanoreactors.

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页码：2868 / +

页数：5

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