Phosphoinositide 3-kinase signalling in the vascular system

被引：176

作者：

Morello, Fulvio ^{[1
]}

Perino, Alessia ^{[1
]}

Hirsch, Emilio ^{[1
]}

机构：

[1] Univ Torino, Ctr Mol Biotechnol, I-10126 Turin, Italy

来源：

CARDIOVASCULAR RESEARCH | 2009年 / 82卷 / 02期

关键词：

Vascular system; Signal transduction; Endothelium; Smooth muscle; Platelets; Atherosclerosis; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; STRESS STIMULATES PHOSPHORYLATION; HUMAN ENDOTHELIAL-CELLS; GROWTH-FACTOR; PHOSPHATIDYLINOSITOL; 3-KINASE; SHEAR-STRESS; SPHINGOSINE; 1-PHOSPHATE; SEQUENTIAL ACTIVATION; CORONARY-ARTERIES;

D O I：

10.1093/cvr/cvn325

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) are protein and lipid kinases activated by different classes of membrane receptors, including G-protein coupled and tyrosine kinase receptors. Several lines of evidence have uncovered specific roles for distinct PI3K isoforms in the vascular system in both physiology and disease. The present review will summarize and discuss the most recent advances regarding PI3K-Akt signalling in endothelial cells, vascular smooth muscle cells, platelets, and inflammatory cells involved in the atherosclerotic process. Of interest, the development of novel isoform-selective PI3K inhibitor drugs offers a unique opportunity to selectively and differentially target PI3K-driven pathways in the vascular system and may give rise to new strategies for the treatment of cardiovascular diseases.

引用

页码：261 / 271

页数：11

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