Synthesis of the benzo[b]fluorene core of the kinamycins by cycloaromatization of non-conjugated benzotriynes

被引：41

作者：

Rodríguez, D

Castedo, L

Domínguez, D ^{[1
]}

Saá, C

机构：

[1] Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela, Spain

[2] Univ Santiago de Compostela, Fac Quim, CSIC, Unidad Asociada, Santiago De Compostela, Spain

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 43期

关键词：

benzo[b]fluorene; enediynes; enetriynes; kinamycin; radical cycloaromatization;

D O I：

10.1016/S0040-4039(99)01570-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Non-conjugated benzotriynes 2 undergo a novel radical cycloaromatization to provide the benzo[b]fluorene core of the kinamycins. The overall process involves a thermal intramolecular cyclization to the non-benzenoid biradicals 4 followed by radical cyclization and hydrogen abstraction. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7701 / 7704

页数：4