Copper-Catalyzed Synthesis of Imidazo[1,2-a]pyridines through Tandem Imine Formation-Oxidative Cyclization under Ambient Air: One-Step Synthesis of Zolimidine on a Gram-Scale

被引：234

作者：

Bagdi, Avik Kumar ^{[1
]}

Rahman, Matiur ^{[1
]}

Santra, Sougata ^{[1
]}

Majee, Adinath ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 09期

关键词：

ambient air; copper; cyclization; imidazo[1; 2-a]pyridines; oxidative amination; zolimidine; N BOND FORMATION; ONE-POT SYNTHESIS; C-H AMINATION; BETA-KETO-ESTERS; DIRECT ARYLATION; FUNCTIONALIZATION; 2-AMINOPYRIDINES; ROUTE; DIAMINATION; BROMIDES;

D O I：

10.1002/adsc.201300298

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new copper-catalyzed oxidative cyclization via CH amination between 2-aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2-a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one-pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale.

引用

页码：1741 / 1747

页数：7

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