One-pot synthesis of imidazo[1,2-a]pyridines from benzyl halides or benzyl tosylates, 2-aminopyridines and isocyanides

被引：89

作者：

Adib, Mehdi ^{[1
]}

Sheikhi, Ehsan ^{[1
]}

Rezaei, Narjes ^{[1
]}

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 25期

关键词：

Benzyl halides; Benzyl tosylates; Kornblum oxidation; Isocyanides; 2-Aminopyridines; Imidazo[1,2-a]pyridines; Three-component reactions; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; ANNULATED PYRIDINES; SELECTIVE METHOD; ALKYL-HALIDES; ISONITRILES; OXIDATION; ALDEHYDES; PYRAZINES;

D O I：

10.1016/j.tetlet.2011.04.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot synthesis of imidazo[1,2-a]pyridines is described. Benzyl halides or benzyl tosylates are oxidized to aldehydes under mild Kornblum conditions which then undergo a three-component reaction with various 2-aminopyridines and isocyanides to afford the imidazo[1,2-a]pyridines in excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

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收藏

页码：3191 / 3194

页数：4

相关论文

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