A novel, one-pot, solvent-, and catalyst-free synthesis of 2-aryl/alkyl-4(3H)-quinazolinones

被引：51

作者：

Adib, Mehdi ^{[1
]}

Ansari, Samira ^{[1
]}

Mohammadi, Ali ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 01期

关键词：

Anthranilic acids; Nitriles; Amidoximes; 2-Aryl/alkyl-4(3H)-quinazolinones; Solvent-free; Catalyst-free; MICROWAVE IRRADIATION; 3-COMPONENT SYNTHESIS; FACILE SYNTHESIS; ISOCYANIDES; EFFICIENT; DERIVATIVES;

D O I：

10.1016/j.tetlet.2009.06.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A novel and one-pot synthesis of 2-aryl/alkyl-4(3H)-quinazolinones is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with anthranilic acids under solvent- and catalyst-free conditions to produce the title compounds in excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：30 / 32

页数：3

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