A novel, one-pot, three-component synthesis of 1,2,4-oxadiazoles under microwave irradiation and solvent-free conditions

被引：44

作者：

Adib, Mehdi ^{[1
]}

Mahdavi, Mohammad

Mahmoodi, Niusha

Pirelahi, Hooshang

Bijanzadeh, Hamid Reza

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2006年 / 11期

关键词：

Meldrum's acids; nitriles; 1,2,4-oxadiazoles; three-component reaction; solvent-free synthesis;

D O I：

10.1055/s-2006-944200

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A novel synthesis of 3,5-disubstituted 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and Meldrum's acids under microwave irradiation and solvent-free conditions in good to excellent yields.

引用

页码：1765 / 1767

页数：3

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