Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylates using a multi-component reaction in water

被引：61

作者：

Adib, Mehdi ^{[1
]}

Sheikhi, Ehsan ^{[1
]}

Kavoosi, Azadeh ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON | 2010年 / 66卷 / 47期

关键词：

Furans; Isocyanides; Dialkyl acetylenedicarboxylates; 2 Hydroxy aromatic aldehydes; Meldrum s acid; Multi component reactions; Synthesis in water; ONE-POT SYNTHESIS; SUBSTITUTED FURANS; FACILE SYNTHESIS; DERIVATIVES; CYCLOISOMERIZATION; CONSTRUCTION; ISOCYANIDES; CYCLIZATION; INHIBITORS; ALDEHYDES;

D O I：

10.1016/j.tet.2010.09.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino)-3 4-furandicarboxylates via a one-pot multi-component reaction is described The reactive 1 1 zwitterionic intermediate generated from the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped at room temperature by coumarin-3-carboxylic acids prepared in situ from a 2-hydroxy aromatic aldehyde and Meldrum s acid to afford the tale compounds in good to excellent yields (C) 2010 Published by Elsevier Ltd

引用

页码：9263 / 9269

页数：7

共 49 条

[1] A novel, one-pot, solvent-, and catalyst-free synthesis of 2-aryl/alkyl-4(3H)-quinazolinones [J].