Effect of the length of alkyl chain on the cytochrome P450 dependent metabolism of N-dialkylnitrosamines

被引：18

作者：

Bellec, G ^{[1
]}

Goasduff, T ^{[1
]}

Dreano, Y ^{[1
]}

Menez, JF ^{[1
]}

Berthou, F ^{[1
]}

机构：

[1] FAC MED,LAB BIOCHIM NUTR,F-29285 BREST,FRANCE

来源：

CANCER LETTERS | 1996年 / 100卷 / 1-2期

关键词：

N-nitrosamines; formaldehyde; aldehydes; catalytic activities; cytochromes P450;

D O I：

10.1016/0304-3835(95)04078-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl amines) and four asymmetrical (N-nitroso-methylethyl, methylpropyl, methylbutyl, and methylamyl-amines), into aldehydes. Thus, the longer the alkyl chain of symmetrical N-nitrosamines, the smaller was the metabolic rate of the corresponding aldehyde formation. The chain length of the alkyl group of N-nitroso-methylalkylamines modified the oxidation of the alkyl moiety; the oxidation by CYP2E1 decreased as the n-alkyl chain length increased and conversely for the oxidation by CYP1A and CYP2B. Finally, the longer the n-alkyl chain of asymmetrical N-nitrosamines, the greater was the oxidation of methyl groups.

引用

页码：115 / 123

页数：9

共 23 条

[1] COMPARISON OF CAFFEINE METABOLISM BY SLICES, MICROSOMES AND HEPATOCYTE CULTURES FROM ADULT HUMAN-LIVER [J].