The beta-amino acid, (S)-ethyl-3-amino-4-pentynoate: is a chiral synthon used in the synthesis of xemilofiban hydrochloride, an anti-platelet agent. A biocatalytic approach was developed to resolve (R)- and (S)-enantiomers of ethyl 3-amino-4-pentynoate in enantiomerically pure form employing the enzyme Penicillin acylase. In the acylation, phenylacetic acid was used as an acylating agent. We have shown that both the acylation and deacylation can be employed and that the activity of the enzyme Penicillin acylase can be controlled by maintaining an appropriate pH of the reaction medium. (C) 1999 Elsevier Science Ltd. All rights reserved.
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
AMOROSO, R
CARDILLO, G
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
CARDILLO, G
SABATINO, P
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
SABATINO, P
TOMASINI, C
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
TOMASINI, C
TRERE, A
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
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Univ of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, SwedUniv of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, Swed
Andersson, Elis
Mattiasson, Bo
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Univ of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, SwedUniv of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, Swed
Mattiasson, Bo
Hahn-Hagerdal, Barbel
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Univ of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, SwedUniv of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, Swed
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
AMOROSO, R
CARDILLO, G
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
CARDILLO, G
SABATINO, P
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
SABATINO, P
TOMASINI, C
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
TOMASINI, C
TRERE, A
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UNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALYUNIV BOLOGNA,DIPARTIMENTO CHIM G CIAMICIAN,CTR STUDIO FIS MACROMOLEC,I-40126 BOLOGNA,ITALY
机构:
Univ of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, SwedUniv of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, Swed
Andersson, Elis
Mattiasson, Bo
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Univ of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, SwedUniv of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, Swed
Mattiasson, Bo
Hahn-Hagerdal, Barbel
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Univ of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, SwedUniv of Lund, Chemical Cent, Lund,, Swed, Univ of Lund, Chemical Cent, Lund, Swed