New triterpenoids from the stems and leaves of Panax ginseng

被引:59
作者
Li, Ke-Ke [1 ,2 ]
Yang, Xin-Bao [3 ,4 ]
Yang, Xiu-Wei [1 ]
Liu, Jian-Xun [3 ,4 ]
Gong, Xiao-Jie [2 ]
机构
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs,Dept Nat Med, Beijing 100871, Peoples R China
[2] Dalian Univ Technol, Sch Med, Dalian 116622, Peoples R China
[3] Beijing Univ Chinese Med, Beijing 100029, Peoples R China
[4] China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China
关键词
Panax ginseng; Araliaceae; Dammarane triterpenoids; Saponin; SAPONINS; MICE;
D O I
10.1016/j.fitote.2012.05.013
中图分类号
R914 [药物化学];
学科分类号
100705 [微生物与生化药学];
摘要
Three new dammarane-type triterpene saponins ginsenosides Rh-18 (1), Rh-19 (3) and Rh-20 (4), along with two new triterpene sapogenins 12 beta,23(R)-epoxydammara-24-ene-3 beta,6 alpha,20(S)-triol (2) and dammara-(20E)22,25-diene-3 beta,6 alpha,12 beta,24S-tetrol (5) were isolated from the stems and leaves of Panax ginseng C. A. Mey. Their structures were elucidated on the basis of spectral evidence and comparisons with literature data. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:1030 / 1035
页数:6
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