Bone's Material Constituents and their Contribution to Bone Strength in Health, Disease, and Treatment

被引:65
作者
Bala, Y. [1 ,2 ]
Seeman, E. [3 ,4 ]
机构
[1] Inst Natl Sci Appl, Lab Vibrat Acoust, F-69621 Villeurbanne, France
[2] Univ Lyon, INSERM UMR1033, Lyon, France
[3] Univ Melbourne, Austin Hlth, Dept Endocrinol, Melbourne, Vic 3081, Australia
[4] Univ Melbourne, Austin Hlth, Dept Med, Melbourne, Vic 3081, Australia
关键词
Bone water; Collagen; Mineralization; Osteopontin; Osteocalcin; Pentosidine; Qualities of bone; HUMAN CORTICAL BONE; COLLAGEN CROSS-LINKING; MINERALIZATION DENSITY DISTRIBUTION; GLYCATION-INDUCED-PENTOSIDINE; ILIAC CREST BIOPSIES; AGE-RELATED-CHANGES; X-RAY-SCATTERING; CANCELLOUS BONE; OSTEOGENESIS IMPERFECTA; PARATHYROID-HORMONE;
D O I
10.1007/s00223-015-9971-y
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Type 1 collagen matrix volume, its degree of completeness of its mineralization, the extent of collagen crosslinking and water content, and the non-collagenous proteins like osteopontin and osteocalcin comprise the main constituents of bone's material composition. Each influences material strength and change in different ways during advancing age, health, disease, and drug therapy. These traits are not quantifiable using bone densitometry and their plurality is better captured by the term bone 'qualities' than 'quality'. These qualities are the subject of this manuscript.
引用
收藏
页码:308 / 326
页数:19
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