Highly selective intermolecular Heck reaction for the soluble polymer supported synthesis of glutamic acid analogues

被引：12

作者：

Sauvagnat, B

Lamaty, F

Lazaro, R

Martinez, J

机构：

[1] Univ Montpellier I, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier, France

[2] Univ Montpellier 2, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 48期

关键词：

poly(ethylene glycol); supported synthesis; palladium; Heck reaction; glutamic acid;

D O I：

10.1016/S0040-4020(01)00984-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Analogues of the neurotransmitter glutamic acid were synthesized by performing a Heck reaction on 4-methylene glutamic acid analogue. This reaction has proved to be highly regio- and stereoselective in the formation of trisubstituted olefin derivatives. A soluble polymer supported substrate yielded similar results and provided an efficient method for the parallel synthesis of novel glutamic acid derivatives. Furthermore a one-pot Pd-catalyzed alkylation/Heck arylation sequence has been developed. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：9711 / 9718

页数：8

共 46 条

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