Dynamics of Hippocampal Neurogenesis in Adult Humans

被引：1447

作者：

Spalding, Kirsty L. ^{[1
]}

Bergmann, Olaf ^{[1
]}

Alkass, Kanar ^{[1
,2
]}

Bernard, Samuel ^{[3
]}

Salehpour, Mehran ^{[4
]}

Huttner, Hagen B. ^{[1
,5
]}

Bostrom, Emil ^{[1
]}

Westerlund, Isabelle ^{[1
]}

Vial, Celine ^{[3
]}

Buchholz, Bruce A. ^{[6
]}

Possnert, Goran ^{[4
]}

Mash, Deborah C. ^{[7
]}

Druid, Henrik ^{[2
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Oncol Pathol, S-17177 Stockholm, Sweden

[3] Univ Lyon, CNRS UMR 5208, Inst Camille Jordan, F-69622 Villeurbanne, France

[4] Uppsala Univ, Dept Phys & Astron, S-75120 Uppsala, Sweden

[5] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany

[6] Lawrence Livermore Natl Lab, Ctr Accelerator Mass Spectrometry, Livermore, CA 94550 USA

[7] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

来源：

CELL | 2013年 / 153卷 / 06期

基金：

欧洲研究理事会; 瑞典研究理事会; 美国国家卫生研究院;

关键词：

ENHANCED SYNAPTIC PLASTICITY; GRANULE CELLS; OLFACTORY-BULB; DENTATE GYRUS; NEURONS; C-14; AGE; RADIOCARBON; BRAIN;

D O I：

10.1016/j.cell.2013.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclearbomb-test-derived C-14 in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.

引用

页码：1219 / 1227

页数：9

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