Surface plasmon resonance based biosensor technique: A review

被引：329

作者：

Guo, Xiaowei ^{[1
,2
,3
]}

机构：

[1] Seoul Natl Univ, Sch Elect Engn & Comp Sci, Seoul 151744, South Korea

[2] Seoul Natl Univ, Coll Engn, Seoul 151744, South Korea

[3] Univ Elect Sci & Technol, Sch Optoelect & Informat, Chengdu 610054, Peoples R China

来源：

JOURNAL OF BIOPHOTONICS | 2012年 / 5卷 / 07期

关键词：

Optical biosensor; surface plasmon resonance; microfluidics; optical fiber; nanoparticles; NANOSCALE OPTICAL BIOSENSOR; SELF-ASSEMBLED MONOLAYERS; RANGE DISTANCE DEPENDENCE; GOLD NANOPARTICLE SENSOR; PROTEIN-DNA INTERACTIONS; LABEL-FREE DETECTION; REAL-TIME DETECTION; IMAGING MEASUREMENTS; ULTRASENSITIVE DETECTION; SILVER NANOPARTICLES;

D O I：

10.1002/jbio.201200015

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical Surface plasmon resonance (SPR) biosensors represent the most advanced and developed optical label-free biosensor technology. Optical SPR biosensors are a powerful detection and analysis tool that has vast applications in environmental protection, biotechnology, medical diagnostics, drug screening, food safety and security. This article reviews the recent development of SPR biosensor techniques, including bulk SPR and localized SPR (LSPR) biosensors, for detecting interactions between an analyte of interest in solution and a biomolecular recognition. The concepts of bulk and localized SPs and the working principles of both sensing techniques are introduced. Major sensing advances on biorecognition elements, measurement formats, and sensing platforms are presented. Finally, the discussions on both biosensor techniques as well as comparison of both SPR sensing techniques are made. ((c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

引用

页码：483 / 501

页数：19

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