Palladium(II)-catalyzed aerobic hydroalkoxylation of styrenes containing a phenol

被引：86

作者：

Gligorich, KM ^{[1
]}

Schultz, MJ ^{[1
]}

Sigman, MS ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 09期

关键词：

D O I：

10.1021/ja0585533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An intermolecular Pd-catalyzed hydroalkoxylation of styrenes that contain a phenol is presented. The reaction can be performed on terminal, disubstituted, and trisubstituted olefins in a variety of alcoholic solvents. Initial mechanistic data suggest a mechanism that involves oxidation of the alcoholic solvent to provide a Pd-hydride that inserts into an olefin. This is followed by formation of a quinone methide and subsequent addition of an alcohol to yield the hydroalkoxylated product. Copyright © 2006 American Chemical Society.

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页码：2794 / 2795

页数：2

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