Highly efficient one-pot three-component Mannich reaction in water catalyzed by heteropoly acids

被引：266

作者：

Azizi, N ^{[1
]}

Torkiyan, L ^{[1
]}

Saidi, MR ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran 11365, Iran

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1021/ol060498v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heteropoly acids efficiently catalyzed the one-pot, three-component Mannich reaction of ketones with aromatic aldehydes and different amines in water at ambient temperature and afforded the corresponding beta-amino carbonyl compounds in good to excellent yields and with moderate diastereoselectivity. This method provides a novel and improved modification of the three-component Mannich reaction in terms of mild reaction conditions and clean reaction profiles, using very a small quantity of catalyst and a simple workup procedure.

引用

页码：2079 / 2082

页数：4

共 55 条

[1] HCl-catalyzed stereoselective Mannich reaction in H2O-SDS system [J].