Enzyme-catalyzed formation of glycosidic linkages

被引：65

作者：

Watt, GM ^{[1
]}

Lowden, PAS ^{[1
]}

Flitsch, SL ^{[1
]}

机构：

[1] UNIV EDINBURGH,DEPT CHEM,EDINBURGH CTR PROT TECHNOL,EDINBURGH EH9 3JJ,MIDLOTHIAN,SCOTLAND

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(97)80074-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant progress has recently been achieved in the use of glycosidases and glycosyltransferases as synthetic tools. Glycosidases have been used to synthesize trisaccharides with a reasonable overall yield, as well as high-mannose neoglycoconjugates. Studies on glycosyltransferases have defined reaction mechanisms and demonstrated reasonable substrate tolerance of these enzymes. Effective methodology for the synthesis of defined glycoproteins has also been demonstrated. (C) Current Biology Ltd ISSN 0959-440X

引用

页码：652 / 660

页数：9

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