Amplifier-Mediated Activation of Cell-Penetrating Peptides with Steroids: Multifunctional Anion Transporters for Fluorogenic Cholesterol Sensing in Eggs and Blood

被引：31

作者：

Butterfield, Sara M. ^{[1
]}

Miyatake, Tomohiro ^{[1
]}

Matile, Stefan ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 02期

关键词：

amphiphiles; biosensors; ion transport; membranes; steroids; SYNTHETIC PORES; FLUOROMETRIC DETECTION; ENZYME-ACTIVITY; DRUG-DELIVERY; COMPLEXES; CHEMISTRY; MEMBRANES; ALDEHYDES; BILAYERS; RECEPTOR;

D O I：

10.1002/anie.200804422

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented). Off-the-shelf, prêt-à-porter multianalyte sensing systems are based on the ability of cell-penetrating peptides (CPPs; see picture, blue) to mediate the export of hydrophilic anions (yellow → green) from lipid bilayer vesicles (gray). Covalent capture of hydrophobic analytes (black) with hydrophilic anions (red) produces amphiphilic anions that can activate CPPs. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：325 / 328

页数：4

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