Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors

被引：60

作者：

Liu, JF ^{[1
]}

Wilson, CJ ^{[1
]}

Ye, P ^{[1
]}

Sprague, K ^{[1
]}

Sargent, K ^{[1
]}

Si, Y ^{[1
]}

Beletsky, G ^{[1
]}

Yohannes, D ^{[1
]}

Ng, SC ^{[1
]}

机构：

[1] ArQule Inc, Woburn, MA 01801 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 03期

关键词：

privileged structure; quinazolinone; natural product-templated library; tubulin polymerization inhibitors;

D O I：

10.1016/j.bmcl.2005.10.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：686 / 690

页数：5

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