A microstereolithography resin based on thiol-ene chemistry: towards biocompatible 3D extracellular constructs for tissue engineering

被引：36

作者：

Barker, Ian A. ^{[1
]}

Ablett, Matthew P. ^{[2
]}

Gilbert, Hamish T. J. ^{[2
]}

Leigh, Simon J. ^{[3
]}

Covington, James A. ^{[3
]}

Hoyland, Judith A. ^{[2
]}

Richardson, Stephen M. ^{[2
]}

Dove, Andrew P. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Manchester, Fac Med & Human Sci, Inst Inflammat & Repair, Ctr Tissue Injury & Repair, Manchester M13 9PT, Lancs, England

[3] Univ Warwick, Sch Engn, Coventry CV4 7AL, W Midlands, England

来源：

BIOMATERIALS SCIENCE | 2014年 / 2卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

INTERVERTEBRAL DISC; REGENERATION; SCAFFOLDS; FIBROSUS; CELLS;

D O I：

10.1039/c3bm60290g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

A new class of degradable aliphatic poly(carbonate) resins for use in microstereolithographic process is described. Using a biologically inert photo-inhibiting dye, exemplar 3-dimensional structures were produced using thiol-ene chemistry via microstereolithography. Fabricated constructs demonstrated good biological compatibility with cells and had tensile properties that render them suitable for use as tissue engineering scaffolds.

引用

页码：472 / 475

页数：4

共 20 条

[1]

Porous silk scaffolds can be used for tissue engineering annulus fibrosus [J].

Chang, G. ;

Kim, H. -J. ;

Kaplan, D. ;

Vunjak-Novakovic, G. ;

Kandel, R. A. .

EUROPEAN SPINE JOURNAL, 2007, 16 (11) :1848-1857

[2]

Initiation and kinetics of thiol-ene photopolymerizations without photoinitiators [J].

Cramer, NB ;

Reddy, SK ;

Cole, M ;

Hoyle, C ;

Bowman, CN .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2004, 42 (22) :5817-5826

[3]

Cell transplantation in lumbar spine disc degeneration disease [J].

Hohaus, C. ;

Ganey, T. M. ;

Minkus, Y. ;

Meisel, H. J. .

EUROPEAN SPINE JOURNAL, 2008, 17 (Suppl 4) :S492-S503

[4]

Thiol-Ene Click Chemistry [J].

Hoyle, Charles E. ;

Bowman, Christopher N. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (09) :1540-1573

[5]

Synthesis and characterization of amphiphilic block copolymers with allyl side-groups [J].

Hu, Xiuli ;

Chen, Xuesi ;

Xie, Zhigang ;

Liu, Shi ;

Jing, Xiabin .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2007, 45 (23) :5518-5528

[6]

Fumaric Acid Monoethyl Ester-Functionalized Poly(D,L-lactide)/N-vinyl-2-pyrrolidone Resins for the Preparation of Tissue Engineering Scaffolds by Stereolithography [J].

Jansen, Janine ;

Melchels, Ferry P. W. ;

Grijpma, Dirk W. ;

Feijen, Jan .

BIOMACROMOLECULES, 2009, 10 (02) :214-220

[7]

Photo-polymerized microarchitectural constructs prepared by microstereolithography (μSL) using liquid acrylate-end-capped trimethylene carbonate-based prepolymers [J].

Kwon, IK ;

Matsuda, T .

BIOMATERIALS, 2005, 26 (14) :1675-1684

[8]

Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study [J].

Lee, Chang H. ;

Cook, James L. ;

Mendelson, Avital ;

Moioli, Eduardo K. ;

Yao, Hai ;

Mao, Jeremy J. .

LANCET, 2010, 376 (9739) :440-448

[9]

Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds [J].

Lee, Seung-Jae ;

Kang, Hyun-Wook ;

Park, Jung Kyu ;

Rhie, Jong-Won ;

Hahn, Sei Kwang ;

Cho, Dong-Woo .

BIOMEDICAL MICRODEVICES, 2008, 10 (02) :233-241

[10]

Fabrication of 3-Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System [J].

Leigh, Simon J. ;

Gilbert, Hamish T. J. ;

Barker, Ian A. ;

Becker, Jan M. ;

Richardson, Stephen M. ;

Hoyland, Judith A. ;

Covington, James A. ;

Dove, Andrew P. .

BIOMACROMOLECULES, 2013, 14 (01) :186-192

← 1 2 →