PECAM1+/Sca1+/CD38+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair

被引：19

作者：

Etich, Julia ^{[1
]}

Bergmeier, Vera ^{[1
]}

Frie, Christian ^{[1
]}

Kreft, Sandra ^{[1
]}

Bengestrate, Lena ^{[1
]}

Eming, Sabine ^{[2
,3
]}

Mauch, Cornelia ^{[3
]}

Eckes, Beate ^{[3
]}

Ulus, Hikmet ^{[4
]}

Lund, Frances E. ^{[5
]}

Rappl, Gunter ^{[2
,6
]}

Abken, Hinrich ^{[2
,6
]}

Paulsson, Mats ^{[1
,2
,7
]}

Brachvogel, Bent ^{[1
,2
]}

机构：

[1] Univ Cologne, Fac Med, Ctr Biochem, D-50931 Cologne, North Rhine Wes, Germany

[2] Univ Cologne, Fac Med, Ctr Mol Med Cologne, D-50931 Cologne, North Rhine Wes, Germany

[3] Univ Cologne, Dept Dermatol, D-50931 Cologne, North Rhine Wes, Germany

[4] Clin Paediat Surg, D-50931 Cologne, North Rhine Wes, Germany

[5] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA

[6] Univ Cologne, Fac Med, Dept Internal Med 1, D-50931 Cologne, North Rhine Wes, Germany

[7] Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, North Rhine Wes, Germany

来源：

PLOS ONE | 2013年 / 8卷 / 01期

关键词：

SURFACE ANTIGEN CD38; PERIVASCULAR CELLS; ENDOTHELIAL-CELLS; POPULATION; EXPRESSION; CONTRIBUTE; LIVER; SCA-1;

D O I：

10.1371/journal.pone.0053262

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1(+)/Sca1(+) vascular cell population in mouse skin, which is highly enriched in wounds at the peak of neoangiogenesis and myofibroblast formation. These cells express endothelial and perivascular markers and present the receptor CD38 on their surface. PECAM1(+)/Sca1(+)/CD38(+) cells proliferate upon wounding and could give rise to alpha-SMA(+) myofibroblast-like cells. CD38 stimulation in immunodeficient mice reduced the wound size at the peak of neoangiogenesis and myofibroblast formation. In humans a corresponding cell population was identified, which was enriched in sprouting vessels of basal cell carcinoma biopsies. The results indicate that PECAM1(+)/Sca1(+)/CD38(+) vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. Moreover, CD38 signaling modulates PECAM1(+)/Sca1(+)/CD38(+) cell activation in the healing process implying CD38 as a target for anti-angiogenic therapies in human basal cell carcinoma.

引用

页数：12

共 25 条

[1]

Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages [J].