Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat?

被引：26

作者：

Fodor, M

Delemarre-van de Waal, HA

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Res Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands

[2] Semmelweis Univ, Sch Med, Neuromorphol Lab, H-1450 Budapest, Hungary

来源：

NEUROREPORT | 2001年 / 12卷 / 18期

关键词：

androgen receptor; double immunolabeling; beta-endorphin; estrogen receptor-beta; rat; testosterone;

D O I：

10.1097/00001756-200112210-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Testosterone alters the expression of proopiomelanocortin (POMC) mRNA in the neurons of the arcuate nucleus. While observations suggest that both estrogen and androgen receptors (AR) can mediate this action, only a negligible number of POMC neurons has previously been shown to contain estrogen receptor (ER)alpha. To determine whether the putative action of testosterone is mediated via ER-beta or AR we double immunolabeled hypothalamic sections from col chi ci ne-p retreated male rats. Only few cells were immunostained for ER-beta and they were never found to co-localize POMC. In spite of the overlap in the anatomical distribution, only 3% of POMC cells appeared to contain AR. These results suggest that sex steroids have an indirect effect on most POMC neurons. NeuroReport 12:3989-3991 (C) 2001 Lippincott Williams & Wilkins.

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页码：3989 / 3991

页数：3

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