Protective effect of the extracts from Cnidium officinale against oxidative damage induced by hydrogen peroxide via antioxidant effect

被引：51

作者：

Jeong, Jin Boo ^{[1
]}

Park, Jae Ho ^{[1
]}

Lee, Hee Kyeong ^{[1
]}

Ju, So Yeong ^{[1
]}

Hong, Se Chul ^{[1
]}

Lee, Jeong Rak ^{[1
]}

Chung, Gyu Young ^{[1
]}

Lim, Jae Hwan ^{[1
]}

Jeong, Hyung Jin ^{[1
]}

机构：

[1] Andong Natl Univ, Coll Nat Sci, Andong, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 03期

关键词：

Cnidium officinale; Antioxidant; Reactive oxygen species (ROS); Oxidative DNA damage; Chemoprevention; RADICAL-SCAVENGING ACTIVITIES; HYDROXYL; PRODUCTS; ACID; CYTOTOXICITY; EXPRESSION; TOXICITY; ADDUCTS; OXYGEN; ASSAY;

D O I：

10.1016/j.fct.2008.11.039

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The dried rhizomes of Cnidium officinale are used as herbal drugs in the treatment of pain, inflammation, menstrual disturbance and antivitamin deficiency disease, and also act as a blood pressure depressant. In addition, there are several reports suggesting that they have pharmacological properties to tumor metastasis and angiogenesis, and that they act as an inhibitor of high glucose-induced proliferation of glomerular mesangial cells. However, little has been known about the functional role of the extracts from C. officinale on oxidative DNA damage and apoptosis caused by ROS, In this work, we have investigated the DPPH radical, hydroxyl radical and intracellular ROS scavenging capacity, and Fe2+ chelating activity of the extracts from C officinale. In addition, we evaluated whether the extracts are capable of reducing H2O2-induced DNA and cell damage in the human skin fibroblast cell. These extracts showed a dose-dependent free-radical scavenging capacity and a protective effect on DNA damage and the lipid peroxidation causing the cell damage by ROS. These antioxidant activities and inhibitory effects of the extracts on DNA and cell damage may further explain that C. officinale is useful as a herbal medicine for cancer chemoprevention. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

引用

页码：525 / 529

页数：5

共 31 条

[1]

Cytotoxicity and L-amino acid oxidase activity of crude insect drugs [J].