Emerging roles of epithelial-mesenchymal transition in hematological malignancies

被引：55

作者：

Chen, San-Chi ^{[1
,2
,3
]}

Liao, Tsai-Tsen ^{[1
,4
,5
]}

Yang, Muh-Hwa ^{[1
,3
,4
]}

机构：

[1] Natl Yang Ming Univ, Inst Clin Med, 155 Sec 2,Li Nong St, Taipei 11221, Taiwan

[2] Natl Yang Ming Univ, Fac Med, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Dept Oncol, Div Med Oncol, Taipei, Taiwan

[4] Natl Yang Ming Univ, Canc Progress Ctr Excellence, Taipei, Taiwan

[5] Natl Yang Ming Univ, Dept Otolaryngol, Taipei, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2018年 / 25卷

关键词：

Epithelial-mesenchymal transition; Leukemia; Lymphoma; NF-KAPPA-B; ACUTE MYELOID-LEUKEMIA; CELL SELF-RENEWAL; TRANSCRIPTION FACTOR TWIST; SEZARY-SYNDROME; E-CADHERIN; TGF-BETA; BREAST-CANCER; STEM-CELLS; SIGNALING PATHWAY;

D O I：

10.1186/s12929-018-0440-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Background: Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. ' Main body: Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions: Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma.

引用

页数：8

共 104 条

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Opposing LSD1 complexes function in developmental gene activation and repression programmes [J].