H2AX: functional roles and potential applications

被引：252

作者：

Dickey, Jennifer S. ^{[1
]}

Redon, Christophe E. ^{[1
]}

Nakamura, Asako J. ^{[1
]}

Baird, Brandon J. ^{[1
]}

Sedelnikova, Olga A. ^{[1
]}

Bonner, William M. ^{[1
]}

机构：

[1] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CHROMOSOMA | 2009年 / 118卷 / 06期

关键词：

DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; PHOSPHORYLATED HISTONE H2AX; IONIZING-RADIATION; GENOMIC INSTABILITY; ATAXIA-TELANGIECTASIA; MAMMALIAN-CELLS; GAMMA-H2AX FOCI; IN-VIVO; 11Q23; REARRANGEMENTS;

D O I：

10.1007/s00412-009-0234-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed gamma-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of gamma-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.

引用

页码：683 / 692

页数：10

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