H2AX: functional roles and potential applications

被引：252

作者：

Dickey, Jennifer S. ^{[1
]}

Redon, Christophe E. ^{[1
]}

Nakamura, Asako J. ^{[1
]}

Baird, Brandon J. ^{[1
]}

Sedelnikova, Olga A. ^{[1
]}

Bonner, William M. ^{[1
]}

机构：

[1] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CHROMOSOMA | 2009年 / 118卷 / 06期

关键词：

DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; PHOSPHORYLATED HISTONE H2AX; IONIZING-RADIATION; GENOMIC INSTABILITY; ATAXIA-TELANGIECTASIA; MAMMALIAN-CELLS; GAMMA-H2AX FOCI; IN-VIVO; 11Q23; REARRANGEMENTS;

D O I：

10.1007/s00412-009-0234-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed gamma-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of gamma-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.

引用

页码：683 / 692

页数：10

共 105 条

[81]

Sedelnikova OA, 2003, CANCER BIOL THER, V2, P233

[82] Assessment of DNA damage produced by 125I-triplex-forming oligonucleotides in cells [J].

Sedelnikova, OA ;

Panyutin, IV ;

Neumann, RD ;

Bonner, IM ;

Panyutin, IG .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2004, 80 (11-12) :927-931

[83] Delayed kinetics of DNA double-strand break processing in normal and pathological aging [J].

Sedelnikova, Olga A. ;

Horikawa, Izumi ;

Redon, Christophe ;

Nakamura, Asako ;

Zimonjic, Drazen B. ;

Popescu, Nicholas C. ;

Bonner, William M. .

AGING CELL, 2008, 7 (01) :89-100

[84] γH2AX in cancer cells [J].

Sedelnikova, Olga A. ;

Bonner, William M. .

CELL CYCLE, 2006, 5 (24) :2909-2913

[85] Targeted cytoplasmic irradiation induces bystander responses [J].

Shao, CL ;

Folkard, M ;

Michael, BD ;

Prise, KM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (37) :13495-13500

[86] γ-H2AX in bystander cells -: Not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication [J].

Sokolov, Mykyta V. ;

Dickey, Jennifer S. ;

Bonner, William M. ;

Sedelnikova, Olga A. .

CELL CYCLE, 2007, 6 (18) :2210-2212

[87] Copy number alterations of the H2AFX gene in sporadic breast cancer patients [J].

Srivastava, Niloo ;

Gochhait, Sailesh ;

Gupta, Pawan ;

Bamezai, Rameshwar N. K. .

CANCER GENETICS AND CYTOGENETICS, 2008, 180 (02) :121-128

[88] ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation [J].

Stiff, T ;

O'Driscoll, M ;

Rief, N ;

Iwabuchi, K ;

Löbrich, M ;

Jeggo, PA .

CANCER RESEARCH, 2004, 64 (07) :2390-2396

[89] ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling [J].

Stiff, Thomas ;

Walker, Sarah A. ;

Cerosaletti, Karen ;

Goodarzi, Aaron A. ;

Petermann, Eva ;

Concannon, Pat ;

O'Driscoll, Mark ;

Jeggo, Penny A. .

EMBO JOURNAL, 2006, 25 (24) :5775-5782

[90] Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers [J].

Takagi, Y ;

Futamura, M ;

Yamaguchi, K ;

Aoki, S ;

Takahashi, T ;

Saji, S .

GUT, 2000, 47 (02) :268-271

← 2 3 4 5 6 7 8 9 10 11 →