Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

被引：87

作者：

Czaplewski, Lloyd G. ^{[1
]}

Collins, Ian ^{[1
]}

Boyd, E. Andrew ^{[2
]}

Brown, David ^{[1
]}

East, Stephen P. ^{[2
]}

Gardiner, Mihaly ^{[2
]}

Fletcher, Rowena ^{[1
]}

Haydon, David J. ^{[1
]}

Henstock, Vincent ^{[3
]}

Ingram, Peter ^{[2
]}

Jones, Clare ^{[2
]}

Noula, Caterina ^{[3
]}

Kennison, Leanne ^{[1
]}

Rockley, Chris ^{[3
]}

Rose, Valerie ^{[1
]}

Thomaides-Brears, Helena B. ^{[1
]}

Ure, Rebecca ^{[1
]}

Whittaker, Mark ^{[2
]}

Stokes, Neil R. ^{[1
]}

机构：

[1] Prolysis Ltd, Yarnton OX5 1PF, Oxon, England

[2] Evotec UK Ltd, Abingdon OX14 4SA, Oxon, England

[3] Key Organ Ltd, Highfield Ind Estate, Camelford PL32 9QZ, Cornwall, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Antibacterial; Alkoxybenzamide; FtsZ; 3-Methoxybenzamide; Antibacterial efficiency; SMALL-MOLECULE; ANTIBIOTICS; TUBULIN; CYTOKINESIS; POTENT; TARGET; LIGAND;

D O I：

10.1016/j.bmcl.2008.11.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：524 / 527

页数：4

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