Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex

被引:70
作者
Berger, Thomas K. [1 ]
Perin, Rodrigo [1 ]
Silberberg, Gilad [2 ]
Markram, Henry [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Lab Neural Microcircuitry, Brain Mind Inst, CH-1015 Lausanne, Switzerland
[2] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 22期
关键词
SELF-INHIBITION; NEURONS; CELLS; ATTENUATION; CONNECTIONS; PHYSIOLOGY;
D O I
10.1113/jphysiol.2009.176552
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively uniform. It is not known, however, to what extent stereotypic synaptic pathways resemble each other between cortical areas, and how far they might reflect possible functional uniformity or specialization. Here, we show that frequency-dependent disynaptic inhibition (FDDI) is a generic circuit motif that is present in all neocortical areas we investigated (primary somatosensory, auditory and motor cortex, secondary visual cortex and medial prefrontal cortex of the developing rat). We did find, however, area-specific differences in occurrence and kinetics of FDDI and the short-term dynamics of monosynaptic connections between pyramidal cells (PCs). Connectivity between PCs, both monosynaptic and via FDDI, is higher in primary cortices. The long-term effectiveness of FDDI is likely to be limited by an activity-dependent attenuation of the PC-interneuron synaptic transmission. Our results suggest that the basic construction of neocortical synaptic pathways follows principles that are independent of modality or hierarchical order within the neocortex.
引用
收藏
页码:5411 / 5425
页数:15
相关论文
共 35 条
[21]   Recurrent connection patterns of corticostriatal pyramidal cells in frontal cortex [J].
Morishima, M ;
Kawaguchi, Y .
JOURNAL OF NEUROSCIENCE, 2006, 26 (16) :4394-4405
[22]   Dendritic encoding of sensory stimuli controlled by deep cortical interneurons [J].
Murayama, Masanori ;
Perez-Garci, Enrique ;
Nevian, Thomas ;
Bock, Tobias ;
Senn, Walter ;
Larkum, Matthew E. .
NATURE, 2009, 457 (7233) :1137-U95
[23]  
PAXINOS G, 1998, THEORETICAL RAT BRAI
[24]   Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons [J].
Ren, Ming ;
Yoshimura, Yumiko ;
Takada, Naoki ;
Horibe, Shoko ;
Komatsu, Yukio .
SCIENCE, 2007, 316 (5825) :758-761
[25]  
Reyes A, 1999, J NEUROSCI, V19, P3827
[26]  
Sherwood NM., 1970, STEREOTAXIC ATLAS DE
[27]   Disynaptic inhibition between neocortical pyramidal cells mediated by martinotti cells [J].
Silberberg, Gilad ;
Markram, Henry .
NEURON, 2007, 53 (05) :735-746
[28]  
Sjöström PJ, 2001, NEURON, V32, P1149, DOI 10.1016/S0896-6273(01)00542-6
[29]   Highly nonrandom features of synaptic connectivity in local cortical circuits [J].
Song, S ;
Sjöstrom, PJ ;
Reigl, M ;
Nelson, S ;
Chklovskii, DB .
PLOS BIOLOGY, 2005, 3 (03) :507-519
[30]   Pyramidal neurons: dendritic structure and synaptic integration [J].
Spruston, Nelson .
NATURE REVIEWS NEUROSCIENCE, 2008, 9 (03) :206-221