Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons

被引:60
作者
Ren, Ming [1 ]
Yoshimura, Yumiko [1 ]
Takada, Naoki [1 ]
Horibe, Shoko [1 ]
Komatsu, Yukio [1 ]
机构
[1] Nagoya Univ, Environm Med Res Inst, Dept Neurosci, Nagoya, Aichi 4648601, Japan
关键词
D O I
10.1126/science.1135468
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal ( excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.
引用
收藏
页码:758 / 761
页数:4
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