Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons

被引：60

作者：

Ren, Ming ^{[1
]}

Yoshimura, Yumiko ^{[1
]}

Takada, Naoki ^{[1
]}

Horibe, Shoko ^{[1
]}

Komatsu, Yukio ^{[1
]}

机构：

[1] Nagoya Univ, Environm Med Res Inst, Dept Neurosci, Nagoya, Aichi 4648601, Japan

来源：

SCIENCE | 2007年 / 316卷 / 5825期

关键词：

D O I：

10.1126/science.1135468

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal ( excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.

引用

页码：758 / 761

页数：4

共 30 条

[1] Kainate receptors regulate unitary IPSCs elicited in pyramidal cells by fast-spiking interneurons in the neocortex [J].

Ali, AB ;

Rossier, J ;

Staiger, JF ;

Audinat, E .

JOURNAL OF NEUROSCIENCE, 2001, 21 (09) :2992-2999

[2] Perisomatic glutamatergic axon terminals: A novel feature of cortical synaptology revealed by vesicular glutamate transporter 1 immunostaining [J].

Alonso-Nanclares, L ;

Minelli, A ;

Melone, M ;

Edwards, RH ;

Defelipe, J ;

Conti, F .

NEUROSCIENCE, 2004, 123 (02) :547-556

[3] Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala [J].

Braga, MFM ;

Aroniadou-Anderjaska, V ;

Xie, JW ;

Li, H .

JOURNAL OF NEUROSCIENCE, 2003, 23 (02) :442-452

[4] Effect, number and location of synapses made by single pyramidal cells onto aspiny interneurones of cat visual cortex [J].

Buhl, EH ;

Tamas, G ;

Szilagyi, T ;

Stricker, C ;

Paulsen, O ;

Somogyi, P .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 500 (03) :689-713

[5]

Bureau I, 1999, J NEUROSCI, V19, P653

[6] A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission [J].

Clarke, VRJ ;

Ballyk, BA ;

Hoo, KH ;

Mandelzys, A ;

Pellizzari, A ;

Bath, CP ;

Thomas, J ;

Sharpe, EF ;

Davies, CH ;

Ornstein, PL ;

Schoepp, DD ;

Kamboj, RK ;

Collingridge, GL ;

Lodge, D ;

Bleakman, D .

NATURE, 1997, 389 (6651) :599-603

[7] Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons [J].

Cossart, R ;

Tyzio, R ;

Dinocourt, C ;

Esclapez, M ;

Hirsch, JC ;

Ben-Ari, Y ;

Bernard, C .

NEURON, 2001, 29 (02) :497-508

[8] Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons [J].

Dantzker, JL ;

Callaway, EM .

NATURE NEUROSCIENCE, 2000, 3 (07) :701-707

[9]

DECAMILLI P, 2000, SYNAPSES, pCH2

[10] Neuronal circuits of the neocortex [J].

Douglas, RJ ;

Martin, KAC .

ANNUAL REVIEW OF NEUROSCIENCE, 2004, 27 :419-451

← 1 2 3 →