Chemistry and biological applications of photo-labile organic molecules

被引：224

作者：

Yu, Haitao ^{[1
]}

Li, Jinbo ^{[1
]}

Wu, Dongdong ^{[1
]}

Qiu, Zhenjun ^{[1
]}

Zhang, Yan ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Key Lab Analyt Chem Life Sci, Minist Educ China, Nanjing 210093, Peoples R China

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 02期

基金：

美国国家科学基金会;

关键词：

PHOTOLABILE PROTECTING GROUPS; REGULATING GENE-EXPRESSION; SINGLE DENDRITIC SPINES; LONG-TERM POTENTIATION; PHOTOCHEMICAL PROPERTIES; 2-PHOTON EXCITATION; ZEBRAFISH EMBRYOS; USEFUL CHELATORS; CAGED GLUTAMATE; CROSS-SECTIONS;

D O I：

10.1039/b901255a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photo-labile molecules have been widely used not only in organic synthesis but also in biological study. The chemistry of the typical photo-labile organic molecules, including their structure, mechanism underlying their photo-lability and strategies to integrate them with biomolecules, is reviewed to illustrate the structural basis for photo-activable caged compounds. Biological applications of representative photo-labile caged molecules were also illustrated for a general understanding on the important roles of caged compounds in dynamic biological studies. This tutorial review would provide an interdisciplinary overview on the important area of chemical biological study making use of photo-labile caged compounds.

引用

页码：464 / 473

页数：10

共 51 条

[31]

Morrison H.A., 1970, The chemistry of the Nitro and Nitroso Groups

[32] Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function [J].