Triplex-directed covalent cross-linking of a DNA nanostructure

被引：21

作者：

Rusling, David A. ^{[1
]}

Nandhakumar, Iris S. ^{[2
]}

Brown, Tom ^{[2
]}

Fox, Keith R. ^{[1
]}

机构：

[1] Univ Southampton, Ctr Biol Sci, Southampton, Hants, England

[2] Univ Southampton, Sch Chem, Southampton, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 77期

基金：

英国生物技术与生命科学研究理事会;

关键词：

DOUBLE-HELICAL DNA; NANOSCALE SHAPES; FOLDING DNA; ORIGAMI; NANOTECHNOLOGY; CLEAVAGE;

D O I：

10.1039/c2cc35407a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

引用

页码：9592 / 9594

页数：3