Reaction of nitric oxide with amines

被引：150

作者：

Itoh, T ^{[1
]}

Nagata, K ^{[1
]}

Matsuya, Y ^{[1
]}

Miyazaki, M ^{[1
]}

Ohsawa, A ^{[1
]}

机构：

[1] SHOWA UNIV,SCH PHARMACEUT SCI,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 11期

关键词：

D O I：

10.1021/jo962101e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of nitric oxide (NO) with amines in organic solvents were studied using Hantzsch dihydropyridines and aromatic primary amines as substrates. Hantzsch dihydropyridines are readily oxidized by nitric oxide to give the corresponding pyridines in quantitative yields. The addition of oxygen accelerates the reaction rate considerably. On the other hand, aromatic primary amines give deaminated products by the reaction with nitric oxide only in the presence of oxygen in ethereal solvents or chloroform.

引用

页码：3582 / 3585

页数：4

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