Complex pharmacology of natural cannabinoids:: Evidence for partial agonist activity of Δ9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors

被引：152

作者：

Petitet, F ^{[1
]}

Jeantaud, B ^{[1
]}

Reibaud, M ^{[1
]}

Imperato, A ^{[1
]}

Dubroeucq, MC ^{[1
]}

机构：

[1] Rhone Poulenc Rorer SA, Ctr Rech Vitry Alfortville, Neurochem Dpt, F-94403 Vitry, France

来源：

LIFE SCIENCES | 1998年 / 63卷 / 01期

关键词：

cannabinoid; Delta(9)-tetrahydrocannabinol; cannabinol; cannabidiol; S-35]GTP-gamma-S binding;

D O I：

10.1016/S0024-3205(98)00238-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Delta(9)-tetrahydrocannabinol (Delta(9)-THC), cannabinol and cannabidiol are three important natural cannabinoids from the Marijuana plant (Cannabis sativa). Using [S-35]GTP-gamma-S binding on rat cerebellar homogenate as an index of cannabinoid receptor activation we show that: Delta(9)-THC does not induce the maximal effect obtained by classical cannabinoid receptor agonists such as CP55940. Moreover at high concentration Delta(9)-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range. (C) 1998 Elsevier Science Inc.

引用

页码：PL1 / PL6

页数：6

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