Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola

被引:77
作者
Cazarolli, Luisa Helena [3 ]
Kappel, Virginia Demarchi [1 ]
Pereira, Danielle Fontana [1 ]
Moresco, Henrique Hunger [2 ]
Costa Brighente, Ines Maria [2 ]
Pizzolatti, Moacir Geraldo [2 ]
Mena Barreto Silva, Fatima Regina [1 ]
机构
[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Bioquim, BR-88040970 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil
[3] Univ Fed Fronteira Sul, BR-85303775 Laranjeiras Do S, PR, Brazil
关键词
Averrhoa carambola; Flavonoids; Diabetes; Antihyperglycemic; Glucose uptake; SEMI-PURIFIED FRACTIONS; BAUHINIA-FORFICATA; GLUCOSE-UPTAKE; LEAF EXTRACT; FLAVONOIDS; MECHANISM; GLYCOGEN; BILIMBI; CELLS;
D O I
10.1016/j.fitote.2012.07.003
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A stimulatory effect of apigenin-6-C-beta-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 mu M of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (P13K), RO318220, an inhibitor of protein kinase C (PKC), PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and HNMPA(AM)(3), an insulin receptor tyrosine kinase activity inhibitor showed that apigenin-6-C-beta-fucopyranoside triggers different metabolic pathways in skeletal muscle. The oral administration of crude extract, fractions and isolated flavonoids (apigenin-6-C-beta-fucopyranoside (1) and apigenin-6-C-(2 ''-O-alpha-rhamnopyranosyl)-beta-fucopyranoside (2)) from Averrhoa carambola leaves exhibited a potential hypoglycemic activity in hyperglycemic normal rats. Additionally, both flavonoids significantly increased the muscle and liver glycogen content after an acute treatment. The results indicate that A. carambola can be regarded as a potent anti hyperglycemic agent with insulin secretagogue and insulin mimetic properties. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:1176 / 1183
页数:8
相关论文
共 35 条
[1]   Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice [J].
Bansal, Punit ;
Paul, Piya ;
Mudgal, Jayesh ;
Nayak, Pawan G. ;
Pannakal, Steve Thomas ;
Priyadarsini, K. I. ;
Unnikrishnan, M. K. .
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2012, 64 (06) :651-658
[2]   Flavonoids: Cellular and molecular mechanism of action in glucose homeostasis [J].
Cazarolli, Luisa Helena ;
Zanatta, Leila ;
Alberton, Elga Heloisa ;
Reis Bonorino Figueiredo, Maria Santos ;
Folador, Poliane ;
Damazio, Rosangela Guollo ;
Pizzolatti, Moacir Geraldo ;
Mena Barreto Silva, Fatima Regina .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (10) :1032-1038
[3]   Follow-up studies on glycosylated flavonoids and their complexes with vanadium: Their anti-hyperglycemic potential role in diabetes [J].
Cazarolli, Luisa Helena ;
Zanatta, Leila ;
Jorge, Ana Paula ;
de Sousa, Eliandra ;
Horst, Heros ;
Woehl, Viviane Mara ;
Pizzolatti, Moacir Geraldo ;
Szpoganicz, Bruno ;
Mena Barreto Silva, Fatima Regina .
CHEMICO-BIOLOGICAL INTERACTIONS, 2006, 163 (03) :177-191
[4]   Stimulatory effect of apigenin-6-C-β-L-fucopyranoside on insulin secretion and glycogen synthesis [J].
Cazarolli, Luisa Helena ;
Folador, Poliane ;
Moresco, Henrique Hunger ;
Costa Brighente, Ines Maria ;
Pizzolatti, Moacir Geraldo ;
Barreto Silva, Fatima Regina M. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) :4668-4673
[5]   Mechanism of action of the stimulatory effect of apigenin-6-C-(2"-O-α-L-rhamnopyranosyl)-β-L-fucopyranoside on 14C-glucose uptake [J].
Cazarolli, Luisa Helena ;
Folador, Poliane ;
Moresco, Henrique Hunger ;
Costa Brighente, Ines Maria ;
Pizzolatti, Moacir Geraldo ;
Mena Barreto Silva, Fatima Regina .
CHEMICO-BIOLOGICAL INTERACTIONS, 2009, 179 (2-3) :407-412
[6]   Flavonoids: Prospective Drug Candidates [J].
Cazarolli, Luisa Helena ;
Zanatta, Leila ;
Alberton, Elga Heloisa ;
Reis Bonorino Figueiredo, Maria Santos ;
Folador, Poliane ;
Damazio, Rosangela Guollo ;
Pizzolatti, Moacir Geraldo ;
Mena Barreto Silva, Fatima Regina .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (13) :1429-1440
[7]  
Correa M.P., 1984, DICIONARIO PLANTAS U, P687
[8]   Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(α)-dirhamnoside from Bauhinia forficata leaves [J].
de Sousa, E ;
Zanatta, L ;
Seifriz, I ;
Creezynski-Pasa, TB ;
Pizzolatti, MG ;
Szpoganiez, B ;
Silva, FRMB .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (05) :829-832
[9]   IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor [J].
Diaz, L. E. ;
Chuan, Y-C. ;
LeWitt, M. ;
Fernandez-Perez, L. ;
Carrasco-Rodriguez, S. ;
Sanchez-Gomez, M. ;
Flores-Morales, A. .
MOLECULAR HUMAN REPRODUCTION, 2007, 13 (7-8) :567-576
[10]   Antioxidant and Protective Effects of Major Flavonoids from Teucrium polium on β-Cell Destruction in a Model of Streptozotocin-Induced Diabetes [J].
Esmaeili, Mohammad Ali ;
Zohari, Fereshteh ;
Sadeghi, Heibatollah .
PLANTA MEDICA, 2009, 75 (13) :1418-1420